CD3 (OKT3) As A Marker Of Immune Response Efficiency

Our immune system functions as an effective defense mechanism against disease, but different factors could trigger our immune response to be either in our favor or in opposition to us. 

The CD3 (cluster of differentiation) is a component of the immune which is comprised of 4 distinct chains (CD3-g, CD3-e, CD3 -s, and the ZETA chain). The four chains are associated with a molecule called T-cell receptor (TCR) to form the TCR complex. 

A Glimpse into the Past… -

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In general, CD3 is found within pro-thymocytes (stem cells in which T cells are born from the thymus) to facilitate signals that are essential for the development of T cells and function as a response to pathogens from outside.

It is the CD3 (OKT3 Clone) antibody (Cat# NBP2-24867) that specifically reacts to an epitope of the epsilon subunit. This is essential to the formation of T cells. 

OKT3 has been shown to exhibit immunosuppressive properties, and deficiency in this gene can cause immunodeficiency. Because CD3 is necessary to activate T-cells numerous targets are being examined as immunosuppressant therapy for a variety of autoimmune disorders. 

Additionally, CD family proteins are also utilized to determine the efficacy of the immune response to modifications in microenvironments.

In general, the particular CD3 (OKT3 Clone) antibody is used to identify specific interactions within the TRC, and their subsequent effects on T cell activation, development, and function in response to endogenous and external stimulants.